The National Institutes of Health (NIH), specifically through the National Institute on Drug Abuse (NIDA), has announced a funding opportunity titled "Research on the Neuro-Immune Axis in the context of HIV and Substance Use (R01 Clinical Trial Not Allowed)." This initiative aims to support research that identifies and characterizes neuroimmune networks and communication pathways related to HIV and substance use disorders, with a focus on understanding the interactions between the immune system and the central nervous system exacerbated by substance misuse. The total funding commitment for this opportunity is $2 million for fiscal year 2025, and applications are due by November 13, 2024. Eligible applicants include a diverse range of organizations such as higher education institutions, non-profits, and tribal governments, with further details available through the NIH Grants Information at grantsinfo@nih.gov or via the opportunity's webpage at https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-25-004.html.