The National Institutes of Health (NIH) is offering a funding opportunity for high-priority research at the intersection of HIV and substance use through the National Institute on Drug Abuse (NIDA). This grant (RFA-DA-25-024) focuses on projects that aim to advance HIV/AIDS research, prevention, treatment, and outcomes for individuals using addictive substances. Eligible applicants include various educational and nonprofit institutions, and for-profit organizations, as well as individuals from diverse backgrounds. Funded projects are expected to develop innovative research plans that tackle common health and social challenges, such as stigma and access to care, while enhancing perspectives from diverse populations. The total anticipated budget for this opportunity across multiple fiscal years is $3 million, with an expected number of 3-5 awards. Key application dates include a submission window opening on January 11, 2025, and an expiration date of February 12, 2027. The grant mandates the submission of a Plan for Enhancing Diverse Perspectives (PEDP), emphasizing inclusivity in recruitment and collaboration strategies. The review of applications will assess the overall impact, significance, rigor, and investigator expertise needed to address the focus areas effectively. This funding initiative reflects NIH’s commitment to addressing critical gaps in HIV-related care, particularly among marginalized populations.