Microglial Pathophysiology in Comorbid Substance Use Disorder (SUD) and HIV (R61/R33 Clinical Trial Not Allowed)
ID: 356173Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/356173

Additional Information

http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-25-063.html
Timeline
    Description

    The National Institutes of Health (NIH) is offering a grant opportunity titled "Microglial Pathophysiology in Comorbid Substance Use Disorder (SUD) and HIV (R61/R33 Clinical Trial Not Allowed)" aimed at exploring the interactions between microglial pathophysiology and the comorbidity of SUD and HIV. The primary objective is to generate specific microglial protein profiles and interaction networks to understand how HIV-infected microglia contribute to neuropathologies associated with these conditions. This initiative is critical for advancing therapeutic interventions by addressing significant knowledge gaps in the cellular interactions of HIV and substance use disorders. Up to $2.5 million is available for 3-6 awards, with applications due by July 14, 2025. For further inquiries, interested applicants can contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-25-063.html.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    RFA-DA-25-063.html
    The National Institute on Drug Abuse (NIDA), under the Department of Health and Human Services, announces a funding opportunity (RFA-DA-25-063) focusing on the interaction of microglial pathophysiology in patients with comorbid Substance Use Disorder (SUD) and HIV. This grant aims to explore the protein interaction networks in HIV-infected microglia and their role in cellular signaling disruptions associated with these comorbid conditions. The two-phase approach consists of an R61 phase, where researchers will quantify protein interactions and the R33 phase, extending these analyses to in vivo models. The expectation is to contribute foundational knowledge that may inform future therapeutic interventions. Up to $2.5 million is allocated for 3-6 awards, with eligibility extended to a diverse range of institutions and organizations. Applications are due by July 14, 2025, with stringent adherence to application guidelines required to ensure acceptance. The program seeks to bridge significant knowledge gaps in understanding how HIV and substance use interact at the cellular level, particularly in microglia, to identify viable intervention points for treatment advancements. Ultimately, the initiative aims to leverage advanced protein profiling techniques to address the dual challenges of HIV and substance use disorders effectively.
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