Microglial Pathophysiology in Comorbid Substance Use Disorder (SUD) and HIV (R61/R33 Clinical Trial Not Allowed)
ID: 349481Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/349481

Additional Information

http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-25-014.html
Timeline
    Description

    The National Institutes of Health (NIH) is offering a grant opportunity titled "Microglial Pathophysiology in Comorbid Substance Use Disorder (SUD) and HIV (R61/R33 Clinical Trial Not Allowed)" aimed at exploring the molecular mechanisms by which HIV-infected microglia contribute to neuropathologies associated with co-occurring HIV and SUD. This initiative seeks to generate specific microglial protein profiles and interaction networks to better understand the impact of these conditions on brain function, utilizing a two-phased approach that includes both preliminary and extended analyses. A total funding amount of $2.5 million is available for 3-6 awards, with proposals due by August 15, 2025. Interested applicants can find more information and submit inquiries via email at grantsinfo@nih.gov or visit the official announcement at https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-25-014.html.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    RFA-DA-25-014-Full-Announcement.html
    RFA-DA-25-014.html
    The National Institute on Drug Abuse (NIDA) is offering a funding opportunity to explore microglial pathophysiology in individuals with co-occurring HIV and substance use disorder (SUD). This grant, identified as RFA-DA-25-014, focuses on studying protein interaction networks within HIV-infected microglia, examining how host-viral interactions contribute to altered cellular signaling specific to brain regions affected by these conditions. The program consists of a two-phased approach: the R61 phase will focus on measuring protein interactions and effects of HIV and drug exposure, while the R33 phase will extend these analyses to in vivo models. The funding opportunity encourages applications from various organizations, including higher education institutions and nonprofits, with an emphasis on incorporating innovative approaches and quantitative protein profiling techniques. A total of $2.5M is designated for 3-6 awards, and proposals must be submitted electronically by August 15, 2025. The application will be evaluated on significance, investigator qualifications, innovation, approach, and the research environment. This initiative aims to fill knowledge gaps surrounding microglial functions related to HIV and SUD, ultimately contributing to potential therapeutic interventions.
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