The National Institutes of Health (NIH) is offering a funding opportunity titled "Targeting Inflammasomes in HIV and Substance Use (R21 Clinical Trial Not Allowed)" aimed at advancing research on the role of inflammasomes in the context of HIV infection and substance use disorders. This initiative seeks to enhance understanding of the mechanisms by which inflammasomes contribute to neuroinflammation and immune dysregulation, with a focus on identifying molecular markers and potential therapeutic targets. Eligible applicants include a diverse range of organizations, such as higher education institutions, community-based organizations, and tribal governments, with funding available up to $500,000 over a two-year project period. The application deadline is March 13, 2025, and interested parties can find more information and guidelines at the NIH grants website or contact NIH Grants Information at grantsinfo@nih.gov.