Mechanistic Exploration of Therapeutic Targets and Treatable Traits to Improve CNS Outcomes in People with HIV

The National Institutes of Health (NIH) is offering a grant opportunity titled "Mechanistic Exploration of Therapeutic Targets and Treatable Traits to Improve CNS Outcomes in People with HIV." This initiative aims to support research that identifies modifiable targets and mechanisms to alleviate central nervous system (CNS) complications in individuals living with HIV, leveraging patient-derived data and innovative model platforms. The program emphasizes the importance of understanding the multifactorial nature of CNS dysfunction and seeks to accelerate the development of effective interventions through clinical studies or pre-clinical models. The estimated total funding for this program is $3 million, with approximately six awards expected. Interested applicants, particularly those with expertise in systems biology and translational neurobiology, should prepare for the upcoming Notice of Funding Opportunity (NOFO), with applications anticipated to open in September 2025. For further inquiries, potential applicants can contact Vasudev R Rao at vasudev.rao@nih.gov or by phone at 301-825-3259.