The Department of Health and Human Services, through the National Institutes of Health (NIH), is issuing a funding opportunity titled "Development & Testing of Novel Interventions to Improve HIV Prevention, Treatment, and Program Implementation for People Who Use Substances" under the R34 planning grant mechanism. This initiative encourages research that develops and tests innovative interventions targeting HIV prevention and care, particularly for populations that engage in substance use. The funding aims to address critical gaps in HIV care and prevention, including integration with substance use disorder treatments and improving the reach of interventions. Eligible organizations include higher education institutions and nonprofit entities, with grants offering up to $450,000 for three years. Applications must include a "Plan for Enhancing Diverse Perspectives," focusing on inclusivity in research. The application cycle starts on April 7, 2025, with subsequent due dates throughout the year. The NIH emphasizes the need for pilot studies addressing the complex relationship between substance use and HIV, aiming for scalable and sustainable solutions. The program underscores a collaborative approach, involving community stakeholders and end users to enhance the efficacy and accessibility of interventions.