The Department of Health and Human Services is issuing a Notice of Funding Opportunity (NOFO) through the NIH to support research on HIV-related comorbidities in populations experiencing health disparities. The initiative emphasizes multilevel and multidisciplinary interventions focused on improving the quality of life and promoting successful aging among people living with HIV, particularly from racial and ethnic minority backgrounds and lower socioeconomic statuses. Key components include a clinical trial requirement, with a total funding commitment anticipated between $5-6 million for approximately 5-6 awards. Applications should propose innovative strategies to address multiple comorbidities and utilize an intersectional approach for sexual and gender minority groups. Eligible applicants range from higher education institutions to non-profits and government entities. The proposal submission opens on November 11, 2023, and includes multiple specific deadlines for letters of intent and applications. Strong adherence to NIH guidelines is essential, with applicants encouraged to include community engagement in their research designs. The initiative underscores the urgent need to develop effective interventions that address the unique challenges faced by aging populations living with HIV, thus advocating for better healthcare access and quality.