Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)
ID: 358937Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Award Range

$0 - $3M

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/358937

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-25-446.html
Timeline
    Description

    The National Institutes of Health (NIH) is offering a funding opportunity titled "Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)" aimed at supporting research into effective interventions for substance use disorders (SUDs) and overdose. This cooperative agreement encourages applications for preclinical and clinical studies focusing on pharmacotherapies, device-based treatments, digital therapeutics, and behavioral interventions, with the goal of advancing these interventions towards regulatory approval or clinical adoption. The funding amount can reach up to $3 million, and applications are due by 5:00 PM local time, with multiple submission cycles from October 2025 to August 2028. Interested applicants can find more information and contact NIH Grants Information at grantsinfo@nih.gov for inquiries.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    PAR-25-446-Full-Announcement.html
    PAR-25-446.html
    The Department of Health and Human Services (HHS), through the National Institute on Drug Abuse (NIDA) at NIH, has reissued a funding opportunity (PAR-25-446) for research into interventions preventing and treating substance use disorders (SUDs) and overdose. This UG3/UH3 cooperative agreement supports preclinical and clinical studies focusing on pharmacotherapies, device-based treatments, digital therapeutics (DTx), and behavioral interventions (Stages I-III). The goal is to advance candidate interventions towards regulatory approval or clinical adoption, addressing the urgent need for effective SUD treatments. Applications are due by 5:00 PM local time, with multiple cycles from October 2025 to August 2028. Eligibility extends to various organizations, including foreign entities, but excludes applications with foreign subawards/subcontracts. Substantial NIH involvement is expected, with clear milestones required for UG3/UH3 phase transitions. Applications that don't focus on novel target identification, mechanistic studies of addiction neurobiology, alcohol as the sole substance, or behavioral interventions beyond Stage III are not responsive.
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