GrantPostedDiscretionary

Exploratory Clinical Neuroscience Research on Substance Use Disorders (R61/R33 Clinical Trial Optional)

National Institutes of Health
PAR-23-157
Application Deadline
May 7, 2026
54 days left
Days Remaining
54
Until deadline
Award Ceiling
Total Program Funding

Grant Opportunity Analysis

The National Institutes of Health (NIH) is inviting applications for the "Exploratory Clinical Neuroscience Research on Substance Use Disorders" funding opportunity, designated as NOFO PAR-23-157. This initiative aims to support exploratory clinical research focused on understanding the neurobiological mechanisms underlying substance use disorders (SUD), utilizing a phased R61/R33 award structure over a five-year period. The program is particularly relevant in addressing the ongoing public health challenges related to substance use, including the opioid crisis, and seeks innovative projects that explore neural circuitry and behavioral processes associated with SUD. Eligible applicants can include a wide range of institutions, including educational, governmental, nonprofit, and for-profit organizations, with funding potentially reaching $500,000 for the R61 phase and an unrestricted budget for the R33 phase, contingent upon meeting specific milestones. Interested parties should contact NIH Grants Information at grantsinfo@nih.gov and note that the application deadline is June 21, 2023, with subsequent review cycles planned.

Eligible Applicants

Others
Additional Eligibility Information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grant Documents

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AI Summary
The Department of Health and Human Services, through the National Institutes of Health (NIH), invites applications for the "Exploratory Clinical Neuroscience Research on Substance Use Disorders" funding opportunity (NOFO PAR-23-157). This program supports exploratory clinical research aimed at understanding the neurobiological mechanisms of substance use disorders (SUD) over a five-year period under the phased R61/R33 award structure. Eligible applicants can include various educational and governmental institutions, nonprofits, and for-profit organizations. The program seeks innovative projects that address the neurobiology of SUD and their risk factors, including neural circuitry and behavioral processes. Funding can amount to $500,000 for the R61 phase and an unrestricted budget in the R33 phase, contingent upon meeting specific R61 milestones. Applications must propose measurable milestones and demonstrate a pathway from R61 to R33. Key dates include an application deadline of June 21, 2023, with subsequent review cycles. Eligible applicants are encouraged to contact program staff prior to submission, and adherence to guidelines and instructions in the SF424 application guide is essential. This initiative seeks to advance research in response to the ongoing public health challenge surrounding substance use, especially in light of the opioid crisis and emerging substance trends.

Related Grant Opportunities

Project Timeline

postedOriginal Opportunity PostedApr 10, 2023
deadlineApplication DeadlineMay 7, 2026
expiryArchive DateJun 12, 2026

Funding Details

No cost sharing required

Agency & Classification

Agency
National Institutes of Health(HHS-NIH11)
Funding Category
Health
Funding Instrument
Grant

Grantor Contact

CFDA Numbers

93.279

Official Sources