The Centers for Disease Control and Prevention (CDC) is forecasting a cooperative agreement opportunity aimed at enhancing national epidemiologic, surveillance, research, and laboratory capacities in the Kingdom of Eswatini to support ongoing responses to HIV, TB, and emerging public health threats. The initiative seeks to partner with a regional or international institution to bolster the capabilities of the Ministry of Health and other relevant entities, focusing on improving public health surveillance, research capacity, and local epidemiologic skills, particularly in outbreak detection and response. This funding is critical for strengthening Eswatini's public health infrastructure, including the development of strategic plans for laboratory services and emergency preparedness systems. Interested applicants can reach out to Emily Dale at (404) 639-8880 or via email at pepfarfoas@cdc.gov, with an estimated total funding of $5,200,000 for the first year and key deadlines including a synopsis close date of February 17, 2025, and an estimated award date of September 30, 2025.