The Centers for Disease Control and Prevention (CDC) is forecasting a federal grant opportunity aimed at strengthening the organizational capacity of the Ministry of Health in the Kingdom of Eswatini to deliver a sustainable HIV/TB response under the President's Emergency Fund for AIDS Relief (PEPFAR). The initiative seeks to provide technical assistance to enhance the Ministry's ability to plan, coordinate, and manage its HIV/TB programs, focusing on leadership capacity, governance structures, resource mobilization, and workforce planning. This effort is critical for addressing the ongoing challenges posed by HIV and TB epidemics and ensuring effective public health responses in Eswatini. Interested applicants can expect an estimated total funding of $1,200,000 for the first fiscal year, with applications due by February 17, 2025, and should contact Emily Dale at (404) 639-8880 or via email at pepfarfoas@cdc.gov for further information.