The Centers for Disease Control and Prevention (CDC) is offering a funding opportunity aimed at implementing combination prevention solutions to control the HIV epidemic among high-risk populations in South Africa under the President's Emergency Plan for AIDS Relief (PEPFAR). This cooperative agreement seeks to provide targeted interventions, particularly for adolescents aged 10-24, focusing on evidence-based biomedical, behavioral, and structural approaches to reduce new HIV infections and improve health equity. The estimated funding amount for the first year is $25 million, with applications due by February 20, 2025. Interested applicants can reach out to Emily Dale at pepfarfoas@cdc.gov for further information.