The Centers for Disease Control and Prevention (CDC) is offering a funding opportunity to strengthen comprehensive HIV prevention interventions in Malawi under the President's Emergency Plan for AIDS Relief (PEPFAR). The initiative aims to reduce new HIV infections through a combination of biomedical, behavioral, and structural interventions, specifically targeting high-risk populations in districts with significant HIV burdens. This program is crucial for addressing health equity and achieving epidemic control in HIV services, with an anticipated funding amount of $5 million for the first year and the expectation of awarding 1-2 grants over a five-year period. Interested applicants, including state and local governments, nonprofits, and foreign entities, must submit their applications by February 18, 2025, and can direct inquiries to Emily Dale at pepfarfoas@cdc.gov.