The Centers for Disease Control and Prevention (CDC) is offering a funding opportunity aimed at strengthening economic analysis and capacity for managing HIV, tuberculosis (TB), and related health threats in South Africa under the President's Emergency Plan for AIDS Relief (PEPFAR). The initiative seeks to conduct economic evaluations and modeling to enhance program efficiency and inform resource allocation, ultimately improving health services for priority populations affected by HIV and TB. This cooperative agreement, with an estimated budget of $400,000 for the first year, is open to a wide range of applicants, including state and local governments, nonprofits, universities, and for-profit entities, provided the work is conducted in South Africa. Interested applicants must submit their proposals electronically by February 20, 2025, to be considered for funding, and can direct inquiries to Emily Dale at pepfarfoas@cdc.gov.