The Centers for Disease Control and Prevention (CDC) is forecasting a federal grant opportunity aimed at strengthening economic analysis in support of program management for HIV, TB, and related health threats in South Africa under the President's Emergency Plan for AIDS Relief (PEPFAR). This cooperative agreement seeks to enhance the use of economic modeling and analysis to inform program planning, resource allocations, and decision-making processes, ultimately contributing to more efficient management of health programs in South Africa. The initiative is crucial for understanding expenditures and efficiencies related to various health policies, thereby maximizing the impact of interventions against HIV, TB, and other health issues. Interested applicants can reach out to Emily Dale at (404) 639-8880 or via email at pepfarfoas@cdc.gov for further information. The estimated total funding for the first year is approximately $400,000, with applications due by February 17, 2025, and awards expected to be announced by September 30, 2025.