The Centers for Disease Control and Prevention (CDC) is offering a funding opportunity aimed at strengthening the Botswana Ministry of Health (MOH) laboratory and health systems to effectively manage and sustain a quality HIV/TB program under the President's Emergency Plan for AIDS Relief (PEPFAR). The initiative focuses on enhancing laboratory diagnostics, quality management systems, and outbreak management capabilities, with an emphasis on building sustainable health systems that can adapt to evolving public health challenges. This funding opportunity, with an estimated total of $3 million for the first year, is open to various organizations, including government entities and nonprofits, provided the project is conducted in Botswana. Applications are due by February 19, 2025, and interested parties can contact Emily Dale at pepfarfoas@cdc.gov for further information.