The Centers for Disease Control and Prevention (CDC) is forecasting a cooperative agreement opportunity aimed at sustaining HIV and TB epidemic control in Lesotho through health system strengthening and technical assistance under the President's Emergency Plan for AIDS Relief (PEPFAR). The primary objective is to accelerate and sustain HIV epidemic control and reduce TB incidence by implementing interventions that meet unmet needs across the clinical cascade in the districts of Leribe, Berea, Quthing, and Qacha’s Nek, while collaborating with the Ministry of Health to enhance health service delivery. This initiative is crucial for achieving the UNAIDS 95-95-95 targets and aligns with PEPFAR's strategic direction to eliminate HIV/AIDS as a public health threat. Interested applicants can reach out to Emily Dale at (404) 639-8880 or via email at pepfarfoas@cdc.gov, with an estimated total funding of $15 million for the first year and key deadlines including a synopsis close date of February 17, 2025, and an estimated award date of September 30, 2025.