The Centers for Disease Control and Prevention (CDC) has announced a Notice of Funding Opportunity (NOFO) aimed at sustaining HIV and TB epidemic control in Lesotho through health system strengthening and technical assistance under the President's Emergency Plan for AIDS Relief (PEPFAR). The initiative focuses on implementing evidence-based interventions in four targeted districts—Leribe, Berea, Quthing, and Qacha’s Nek—to achieve the UNAIDS 95-95-95 targets while addressing critical public health challenges such as high new infections among young women and inadequate service delivery to key populations. Eligible applicants include state and local governments, nonprofits, and foreign entities, with a total expected funding of $15 million for Year 1, and applications are due by February 20, 2025. For further inquiries, interested parties can contact Emily Dale at pepfarfoas@cdc.gov.