In-Depth Phenotyping and Research Using IMPC-Generated Knockout Mouse Strains Exhibiting Embryonic or Perinatal Lethality or Subviability (R01 Clinical Trial Not Allowed)
ID: 357009Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Award Range

$0 - $500K

Eligible Applicants

Others

Funding Category

Income Security and Social Services

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/357009

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-25-140.html
Timeline
    Description

    The National Institutes of Health (NIH) is offering a funding opportunity for in-depth phenotyping and research using knockout mouse strains that exhibit embryonic or perinatal lethality or subviability, under the R01 Clinical Trial Not Allowed grant mechanism. This initiative aims to encourage applications that leverage the International Mouse Phenotyping Consortium (IMPC) resources to better understand genetic functions related to congenital diseases and structural defects, particularly those affecting embryonic development and fertility. The program is part of a broader effort to catalog mammalian gene function, with an award ceiling of $499,999 per year for projects lasting up to five years. Interested applicants must submit their proposals by January 7, 2026, and can find additional information and guidelines at the NIH grants website or contact NIH Grants Information at grantsinfo@nih.gov.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    PAR-25-140-Full-Announcement.html
    PAR-25-140.html
    The Department of Health and Human Services is issuing a funding opportunity through the National Institutes of Health (NIH) aimed at in-depth research and phenotyping of embryonic lethal and subviable knockout mouse strains produced by the International Mouse Phenotyping Consortium (IMPC). The initiative, which falls under the R01 Research Project Grant, encourages applications that focus on understanding genetic functions related to congenital diseases and structural defects, including fertility issues linked to embryonic development. Key dates for application submissions range from May 5, 2025, to June 5, 2025, with a project duration of up to five years and budgets of up to $499,999 annually. Interested applicants are urged to adhere to specific NIH guidelines, including a resource-sharing plan for generated data and biospecimens. The existing program, KOMP2, expects an increase in available mouse strains and aims to enhance knowledge critical to gene function in human health. Eligible applicants include various higher education institutions and nonprofit organizations, with an emphasis on inclusion from diverse backgrounds. This opportunity reflects NIH's commitment to advancing biomedical research and improving health outcomes through innovative genetic studies.
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