Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)
ID: 357005Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Award Range

$0 - $499K

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/357005

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-24-306.html
Timeline
    Description

    The National Institutes of Health (NIH) is offering a funding opportunity titled "Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)," aimed at improving the utility of mammalian cancer models in translational research. This initiative seeks projects that enhance the accuracy and application of models, such as organoids and tumoroids, to better represent human biology and inform clinical practices, addressing current limitations and fostering innovation in cancer research methodologies. Eligible applicants include a diverse range of organizations, such as higher education institutions and community-based organizations, with a maximum funding amount of $499,000 per year for projects not exceeding five years. Interested parties should submit their applications through Grants.gov, with deadlines beginning January 5, 2025, and can direct inquiries to grantsinfo@nih.gov for further information.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    PAR-24-306-Full-Announcement.html
    PAR-24-306.html
    The National Cancer Institute (NCI), part of the Department of Health and Human Services, is issuing a funding opportunity (PAR-24-306) focused on enhancing mammalian models for translational cancer research. This initiative seeks projects that improve the accuracy and application of these models—such as organoids and tumoroids—in representing human biology and informing clinical practices. Key goals include addressing limitations in current models, innovating new applications, and fostering collaborations through the Oncology Models Forum. The maximum award is $499,000 per year, with a project term not exceeding five years. Applications must comply with specific NIH policies and are restricted to non-clinical research. The submission process is managed through Grants.gov, with deadlines starting from January 5, 2025. This NOFO encourages diverse organizations, including higher education institutions and nonprofits, to contribute to advancements in cancer research and treatment methodologies.
    Similar Opportunities
    Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity titled "Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)." This initiative invites applications aimed at improving the utility of mammalian cancer models, including organoids and tumoroids, to better represent human biology and address translational deficiencies in existing models. The funding seeks to advance cancer research by fostering innovative approaches to validate these models and enhance their clinical relevance, ultimately aiming to improve patient outcomes. Eligible applicants can receive up to $499,000 per year for a maximum of five years, with applications due by September 7, 2026. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/pa-files/PAR-23-281.html.
    Resource-Related Research Projects for Development of Animal Models and Related Materials (R24 Clinical Trials Not-Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Resource-Related Research Projects for Development of Animal Models and Related Materials," aimed at advancing research that develops and enhances animal models relevant to human diseases. The initiative seeks applications that demonstrate the need for and potential impact of broadly applicable resources across multiple NIH Institutes and Centers, emphasizing projects that address diseases affecting multiple body systems rather than those focused on specific diseases or singular NIH interests. Eligible applicants include higher education institutions, nonprofit organizations, and government agencies, with funding available up to $5 million per year. The application deadline is set for January 25, 2025, and interested parties can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries.
    Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research (R01 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is inviting research project applications for the grant opportunity titled "Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research." This initiative aims to support hypothesis-driven projects that develop technologies and resources to improve the validity and applicability of animal research across multiple organ systems and diseases, addressing critical gaps identified in previous workshops. The funding is crucial for enhancing research methodologies in biomedical applications, with awards available for up to five years and a maximum budget of $500,000, requiring pre-approval for requests exceeding this amount. Interested applicants can find more information and application guidelines at the NIH Grants Information website or contact grantsinfo@nih.gov, with the application deadline set for September 7, 2025.
    Development of Animal Models and Related Biological Materials for Research (R21 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering the R21 Exploratory/Developmental Research Grant (PAR-21-167) to support innovative research aimed at developing animal models and related biological materials for biomedical studies. This funding opportunity encourages projects that enhance understanding of human health and diseases by creating models that evaluate multiple body systems or diseases affecting them, rather than focusing on a single disease or NIH Institute. With a funding ceiling of $200,000 available for direct costs over a maximum project duration of two years, eligible applicants include higher education institutions, non-profits, and various governmental organizations. The application deadline is January 7, 2025, and interested parties can reach out to the NIH OER Webmaster at FBOWebmaster@OD.NIH.GOV for further inquiries.
    NCI Clinical and Translational Exploratory/Developmental Studies (R21 Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity through the R21 Clinical Trial Optional mechanism, aimed at supporting exploratory and developmental research in cancer diagnosis, treatment, imaging, symptom management, and prevention. This grant is designed to encourage innovative studies that challenge existing paradigms and address critical barriers in cancer research, particularly focusing on reducing disparities among underserved populations. Eligible applicants include a wide range of organizations, such as historically black colleges, tribal governments, and faith-based organizations, with a maximum funding amount of $275,000 available over a two-year period. Interested parties can find more information and application details at the provided link, with a submission deadline of July 1, 2025, and inquiries directed to the NIH OER Webmaster at OERWebmaster03@od.nih.gov.
    NCI Clinical and Translational Exploratory/Developmental Studies (R21 Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH), through the National Cancer Institute (NCI), is offering a funding opportunity titled "NCI Clinical and Translational Exploratory/Developmental Studies (R21 Clinical Trial Optional)" aimed at supporting innovative preclinical and early-phase clinical research in cancer diagnosis, treatment, and prevention. This grant, with a funding ceiling of $275,000 over two years, encourages exploratory studies that may involve significant risk but have the potential to lead to breakthroughs in cancer research, particularly for underserved populations. Applications will be evaluated based on their significance, innovation, and rigor, with key deadlines for submission set for January 2025. Interested applicants can find more information and contact NIH Grants Information at grantsinfo@nih.gov for inquiries.
    Cancer Tissue Engineering Collaborative: Enabling Biomimetic Tissue-Engineered Technologies for Cancer Research (R01 Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Cancer Tissue Engineering Collaborative: Enabling Biomimetic Tissue-Engineered Technologies for Cancer Research," aimed at advancing innovative research in biomimetic tissue-engineered technologies for cancer. This initiative seeks to support collaborative, multidisciplinary projects that integrate regenerative medicine, tissue engineering, and cancer biology to develop advanced in vitro and ex vivo models that accurately mimic human cancer pathophysiology. The funding opportunity is crucial for enhancing cancer research methodologies and understanding disease mechanisms, with a maximum budget of $400,000 per year and a project duration of up to five years. Interested applicants must submit their proposals electronically via Grants.gov by May 8, 2025, and can reach out to the NIH OER Webmaster at OERWebmaster03@od.nih.gov for further inquiries.
    Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research (R01)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH), through the Office of Research Infrastructure Programs (ORIP), has announced a funding opportunity titled "Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research (R01)." This initiative aims to support research project grant applications that focus on developing technologies, tools, and resources to validate animal models and improve the rigor and reproducibility of animal research across various biomedical fields. The program emphasizes hypothesis-driven projects with strong preliminary data and encourages interdisciplinary approaches that align with the interests of multiple NIH Institutes and Centers. Interested applicants must submit their proposals by July 5, 2025, and can find additional information and application guidelines at the NIH grants website or contact NIH Grants Information at grantsinfo@nih.gov.
    Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research (R24 Clinical Trials Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH), through the Office of Research Infrastructure Programs (ORIP), is offering a funding opportunity (PAR-23-039) aimed at developing resources and technologies to enhance the rigor, reproducibility, and translatability of animal models in biomedical research. This initiative encourages applicants to propose broadly applicable technologies that address critical gaps in animal research, focusing on various animal models and ensuring that the proposed resources have significant impact across multiple NIH Institutes and Centers. Successful proposals should demonstrate the necessity and broad applicability of the resources, with project durations of up to four years and no budget limits, although requests exceeding $500,000 require prior approval. Interested applicants can find more information and submit inquiries via email to grantsinfo@nih.gov, with the application deadline set for May 25, 2025.
    Centers for Precision Disease Modeling (U54) (Clinical Trials Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity for the Centers for Precision Disease Modeling (U54), aimed at advancing personalized medicine through the integration of animal genomics with human disease research. This initiative invites applications for cooperative agreements that will support collaborative research projects, enhancing preclinical studies by utilizing precision animal models to evaluate disease-causing variants. The program emphasizes the importance of bridging laboratory research with clinical applications to improve patient care, with each application eligible for funding up to $1,250,000 annually over a maximum project period of five years. Proposals are due by December 15, 2024, and interested applicants can find more information by contacting NIH Grants Information at grantsinfo@nih.gov or visiting the opportunity's webpage at https://grants.nih.gov/grants/guide/pa-files/PAR-24-305.html.