Preclinical Proof of Concept Studies for Rare Diseases (R21 Clinical Trial Not Allowed)
ID: 353369Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Award Range

$0 - $275K

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/353369

Additional Information

http://grants.nih.gov/grants/guide/rfa-files/RFA-TR-24-023.html
Timeline
    Description

    The National Institutes of Health (NIH) is offering a funding opportunity for preclinical proof of concept studies focused on rare diseases through the R21 Exploratory/Developmental Research Grant mechanism. This initiative aims to support efficacy studies in established rare disease models to validate therapeutic agents, including small molecules and biologics, that address significant unmet medical needs. With approximately 30 million Americans affected by rare diseases, this funding opportunity seeks to bridge the gaps in drug development and propel promising agents towards clinical trials. Interested applicants can apply for a maximum budget of $275,000 over a two-year project period, with applications opening on May 3, 2024, and a close date of June 2, 2026. For further inquiries, contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/rfa-files/RFA-TR-24-023.html.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    RFA-TR-24-023.html
    The National Institutes of Health (NIH) is issuing a funding opportunity for preclinical proof of concept studies targeting rare diseases through the R21 Exploratory/Developmental Research Grant mechanism. This initiative, designated as RFA-TR-24-023, aims to fund preclinical efficacy studies in established rare disease models. The goal is to demonstrate the viability of therapeutic agents, such as small molecules and biologics, that address significant unmet medical needs. Applications are encouraged from a diverse group of organizations and must include plans for collaboration with a rare disease steering committee. Key dates include an open date for applications starting May 3, 2024, with funding targeted at up to $1.2 million for 3-5 awards in FY 2025. Applications are restricted to non-clinical trial research and must demonstrate the readiness of therapeutic agents through prescribed evidence. The total project period is limited to two years with a maximum budget of $275,000. This funding opportunity recognizes the unique challenges in developing therapeutics for rare diseases, as approximately 30 million Americans are affected by such conditions. The program seeks to bridge funding gaps in drug development to propel promising agents towards clinical trials.
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