The National Institutes of Health (NIH) is offering a funding opportunity titled "Research Projects to Enhance Applicability of Mammalian Models for Translational Research," aimed at improving the utility of mammalian cancer and tumor models in translational research. This initiative encourages applicants to address translational deficiencies in existing mammalian models and propose innovative applications that enhance their relevance to human biology and clinical outcomes. The funding is available for a maximum project period of five years, with an annual budget limit of $499,000, and is open to a wide range of eligible applicants, including various educational institutions, nonprofits, and foreign entities. Interested parties should submit their applications by September 7, 2026, and can direct inquiries to NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at http://grants.nih.gov/grants/guide/pa-files/PAR-23-281.html for further details.