Screening and Functional Validation of Genomic Variants Associated with Human Congenital Anomalies (R01 Clinical Trial Not Allowed)
ID: 356909Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Income Security and Social Services

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/356909

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-25-185.html
Timeline
    Description

    The National Institutes of Health (NIH) is offering a funding opportunity for the screening and functional validation of genomic variants associated with human congenital anomalies through the R01 Clinical Trial Not Allowed grant. This initiative aims to leverage advancements in genomic technologies to identify and validate genetic variants linked to congenital defects, intellectual developmental disabilities, and inborn errors of metabolism, thereby bridging the gap between genetic identification and functional impact on health. Eligible applicants include a wide range of institutions such as universities, nonprofits, and tribal governments, with a maximum budget of $499,999 per project year and a project duration of up to five years. Interested parties should submit their applications by January 7, 2028, and can direct inquiries to NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/pa-files/PAR-25-185.html for further details.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    PAR-25-185.html
    The Department of Health and Human Services is announcing a funding opportunity under the National Institutes of Health, specifically for screening and functional validation of genomic variants associated with human congenital anomalies. This initiative, under the R01 Research Project Grant, aims to leverage advances in genomic technologies to identify genetic variants linked to structural congenital anomalies, intellectual developmental disabilities, and inborn errors of metabolism. By utilizing public databases, investigators are encouraged to conduct laboratory and mechanistic studies to validate these variants. The goal is to bridge the gap between identifying genetic sequence variations and establishing their functional effects on human health. Grant applications should focus on prioritizing and screening genomic variants using advanced in-silico and model organism approaches, supplying comprehensive methodologies for validation. Eligible applicants include universities, nonprofits, and governments, with a maximum budget of $499,999 for each project year, and the project duration can extend to five years. The NIH seeks proposals that will enhance understanding, prevention, and treatment of congenital anomalies, thus advancing precision medicine in pediatric health. Applicants are urged to adhere to specific submission guidelines to ensure compliance and competitiveness in securing this federal funding.
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