Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research (R01 Clinical Trial Not Allowed)
ID: 356850Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Award Range

$0 - $500K

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/356850

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-25-076.html
Timeline
    Description

    The National Institutes of Health (NIH) is inviting research project applications for the grant opportunity titled "Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research." This initiative aims to support hypothesis-driven projects that develop technologies and resources to improve the validity and applicability of animal research across multiple organ systems and diseases, addressing critical gaps identified in previous workshops. The funding is crucial for enhancing research methodologies in biomedical applications, with awards available for up to five years and a maximum budget of $500,000, requiring pre-approval for requests exceeding this amount. Interested applicants can find more information and application guidelines at the NIH Grants Information website or contact grantsinfo@nih.gov, with the application deadline set for September 7, 2025.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    PAR-25-076.html
    The Department of Health and Human Services, through the National Institutes of Health (NIH), is soliciting research project applications aimed at enhancing the rigor, reproducibility, and translatability of animal models in biomedical research. The funding opportunity, titled "Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research," encourages hypothesis-driven projects with strong preliminary data that address critical gaps identified in a workshop organized by the Office of Research Infrastructure Programs (ORIP). Eligible applicants include various types of higher education institutions, nonprofits, and government entities, provided they adhere to application guidelines and registration requirements. Notably, applications must focus on cross-organism and multi-organ system relevance rather than single diseases. Awards can extend up to five years with no budget limit, although requests exceeding $500,000 need pre-approval. Applications will undergo rigorous peer review to assess scientific merit, innovation, and research impact. The initiative reflects ORIP’s commitment to advancing NIH’s mission by improving research infrastructure and methodologies in the field of animal research for biomedical applications.
    Similar Opportunities
    Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)," aimed at improving the utility of mammalian cancer models in translational research. This initiative seeks projects that enhance the accuracy and application of models, such as organoids and tumoroids, to better represent human biology and inform clinical practices, addressing current limitations and fostering innovation in cancer research methodologies. Eligible applicants include a diverse range of organizations, such as higher education institutions and community-based organizations, with a maximum funding amount of $499,000 per year for projects not exceeding five years. Interested parties should submit their applications through Grants.gov, with deadlines beginning January 5, 2025, and can direct inquiries to grantsinfo@nih.gov for further information.
    Animal and Biological Material Resource Centers (P40 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity for the establishment of Animal and Biological Material Resource Centers under the Notice of Funding Opportunity (NOFO) RFA-OD-25-011. This initiative aims to support the creation, preservation, and distribution of high-quality laboratory animals and biological materials, while also integrating new approach methodologies (NAMs) that complement traditional animal-based research. The program is crucial for enhancing research infrastructure and ensuring the availability of resources that facilitate scientific rigor and reproducibility in biomedical research. A total funding amount of $1.3 million is anticipated to support at least two awards annually from FY 2023-2025, with applications due by January 9, 2029. Interested applicants can reach out to the Office of Research Infrastructure Programs at ORIPDCM@mail.nih.gov for further information.
    Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity titled "Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)." This initiative invites applications aimed at improving the utility of mammalian cancer models, including organoids and tumoroids, to better represent human biology and address translational deficiencies in existing models. The funding seeks to advance cancer research by fostering innovative approaches to validate these models and enhance their clinical relevance, ultimately aiming to improve patient outcomes. Eligible applicants can receive up to $499,000 per year for a maximum of five years, with applications due by September 7, 2026. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/pa-files/PAR-23-281.html.
    Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity for Resource-Related Research Projects aimed at developing models and methodologies for studying human health and diseases, specifically through the R24 grant mechanism, which does not allow clinical trials. This initiative, led by the Office of Research Infrastructure Programs (ORIP), seeks applications that focus on creating broadly applicable research models or new approach methodologies (NAMs) that address diseases impacting multiple organ systems, with a requirement that projects demonstrate relevance to two or more NIH Institutes or Centers. The NIH plans to allocate $5 million annually from fiscal years 2026 to 2029, funding at least six awards each year, with a maximum project duration of four years. Interested applicants, excluding foreign organizations, must complete federal registrations prior to submission and can direct inquiries to ORIPDCM@mail.nih.gov.
    Animal and Biological Material Resource Centers (P40) (Clinical Trials Not-Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a grant opportunity titled "Animal and Biological Material Resource Centers" (P40) aimed at supporting specialized colonies of laboratory animals and related resources to enhance scientific rigor and reproducibility in biomedical research. This funding initiative encourages applicants to propose centers that not only continue existing resources but also develop new ones based on the needs of the biomedical research community, providing unique animal models, informatics tools, and biological materials applicable across multiple NIH Institutes. The total funding commitment is anticipated to be $1.3 million over three years, with at least two grants awarded annually, and interested applicants must adhere to strict application guidelines, with submissions accepted until January 28, 2025. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov.
    Utilizing Equipment to Study Environmental Extrinsic Factors and Enhance Rigor and Reproducibility of Animal Research (R24, Clinical Trials Not-Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a grant opportunity titled "Utilizing Equipment to Study Environmental Extrinsic Factors and Enhance Rigor and Reproducibility of Animal Research (R24, Clinical Trials Not-Allowed)." This funding initiative aims to support research that systematically investigates the impact of environmental extrinsic factors, such as temperature and humidity, on animal research outcomes, with the goal of improving the rigor and reproducibility of such studies. Eligible applicants include a wide range of organizations, including higher education institutions and various government entities, with a maximum funding amount of $400,000 available for projects lasting up to four years. Interested parties should submit their applications by September 25, 2026, and can direct inquiries to NIH Grants Information at grantsinfo@nih.gov or visit the opportunity's webpage for more details at https://grants.nih.gov/grants/guide/pa-files/PAR-24-167.html.
    Animal and Biological Material Resource Centers (P40 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is set to announce a funding opportunity for the Animal and Biological Material Resource Centers under the P40 grant mechanism, aimed at supporting projects that develop and maintain animal models and related biological resources. This initiative seeks to enhance the scientific rigor and reproducibility of biomedical research by providing accessible resources, including special colonies of laboratory animals, informatics tools, and new approach methodologies (NAMs) that complement traditional animal-based research. With an estimated total program funding of $1,300,000 and the expectation of awarding two grants, interested small businesses should prepare for the application process, which will open in December 2025, with submissions due by February 2026. For further inquiries, potential applicants can contact Oleg Mirochnitchenko, PhD, at Oleg.mirochnitchenko@nih.gov or by phone at 301-435-0748.
    Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a grant opportunity titled "Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)." This funding aims to support small businesses in developing, characterizing, or improving research models related to human health and diseases, as well as creating new approach methodologies (NAMs) that enhance the accessibility and translational value of experimental research models. The initiative is crucial for advancing biomedical research and ensuring that developed resources are broadly applicable across multiple NIH Institutes or Centers. The estimated total program funding is $5 million, with approximately six awards expected. Interested applicants should prepare to submit their proposals by January 25, 2026, with the anticipated award date set for October 1, 2026. For further inquiries, contact Sige Zou, PhD, at 301-435-0749 or via email at sige.zou@nih.gov.
    Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Development and Validation of Model Systems to Facilitate Neurotherapeutic Discovery (R61/R33 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity titled "Innovation Grants to Nurture Initial Translational Efforts (IGNITE)" aimed at developing and validating model systems for neurotherapeutic discovery. This initiative encourages proposals for animal models or ex vivo systems that accurately replicate the characteristics of specific neurological or neuromuscular disorders, with the goal of enhancing the translational relevance of these models to improve drug development processes. The program utilizes a phased award mechanism (R61/R33) and requires collaboration with clinical experts, along with a Plan for Enhancing Diverse Perspectives (PEDP) to promote inclusivity in research. The total funding available is $750,000 over three years, with a maximum of $499,000 in direct costs per year. Key submission dates begin with the earliest application due date of January 18, 2025. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov.
    Development of Animal Models and Related Biological Materials for Down Syndrome Research (R21 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity for exploratory research grants (R21) aimed at developing animal models and biological materials for Down syndrome (DS) research. This initiative, part of the INCLUDE Project, seeks to enhance understanding of co-occurring conditions associated with DS and improve health outcomes for affected individuals through innovative research. Eligible applicants, including higher education institutions, nonprofits, and local governments, can request up to $200,000 for a single year, with a total project period not exceeding two years. Interested parties should submit their applications by January 7, 2026, and can direct inquiries to NIH Grants Information at grantsinfo@nih.gov.