Building in vivo Preclinical Assays of Circuit Engagement for Application in Therapeutic Development (R01 Clinical Trial Not Allowed)
ID: 357285Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/357285

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-25-035.html
Timeline
    Description

    The National Institutes of Health (NIH) is offering a funding opportunity titled "Building in vivo Preclinical Assays of Circuit Engagement for Application in Therapeutic Development (R01 Clinical Trial Not Allowed)" aimed at enhancing therapeutic development for mental illnesses. This initiative seeks to establish in vivo neurophysiological and behavioral measures that can serve as assays in the early screening phase of treatment development, focusing on optimizing and evaluating innovative measures that reflect neural processes relevant to both preclinical species and humans. The funding is particularly significant as it addresses critical gaps in the therapeutic development pipeline, with eligible applicants including various educational institutions and organizations, and a budget cap of $250,000 in direct costs per year. Interested parties must submit their applications by February 5, 2025, with a maximum project period of five years, and can direct inquiries to grantsinfo@nih.gov for further information.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    PAR-25-035-Full-Announcement.html
    PAR-25-035.html
    The Department of Health and Human Services, through the National Institute of Mental Health (NIMH), is issuing a funding opportunity (PAR-25-035) aimed at establishing in vivo preclinical assays for assessing neurophysiological and behavioral measures relevant to therapeutic development in mental illnesses. This initiative seeks to optimize and evaluate innovative measures that reflect neural processes potentially conserved between preclinical species and humans. The focus is on creating assays that will aid in early screening for treatment candidates, enhancing the relevance and efficiency of the therapeutic development pipeline. Applications are invited from various eligible organizations, including higher education institutions and non-profits, with budgets capped at $250,000 in direct costs per year. The process emphasizes a three-phase approach: identifying measures, evaluating their performance with FDA-approved interventions, and mechanistic testing of the underlying brain circuits involved. Successful proposals will detail timelines for development, making significant contributions to translational neuroscience and addressing gaps in treatment development for mental disorders. The application deadline is set for February 5, 2025, with a maximum project period of five years and no clinical trials allowed under this funding opportunity.
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