The Department of Health and Human Services, through the National Institutes of Health (NIH), has issued a Notice of Funding Opportunity (NOFO) focused on the development of advanced neuromodulation and neurostimulation devices for mental health applications (Funding Opportunity Number PAR-25-287). The initiative aims to stimulate innovation by funding projects that either create novel brain stimulation devices or significantly enhance existing FDA-approved devices. The application process encourages multidisciplinary teams to integrate expertise from neuroscience, engineering, and regulatory affairs. Proposals may include hardware/software development, preclinical testing, and must include a Plan for Enhancing Diverse Perspectives (PEDP) to foster inclusivity. The submission deadlines are set from January 5, 2025, with various review cycles extending through 2028. While budgets are not capped, they must reflect project needs, and projects can last a maximum of five years. NIH policies govern the applications, which must emphasize innovative and significant improvements in brain stimulation techniques while avoiding incremental changes. This funding opportunity underscores the NIH’s mission to transform mental health treatment through advanced research and technology development.