Novel Assays to Address Translational Gaps in Treatment Development (UG3/UH3 Clinical Trial Optional)
ID: 345385Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/345385

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-23-087.html
Timeline
    Description

    The National Institutes of Health (NIH) has announced a funding opportunity titled "Novel Assays to Address Translational Gaps in Treatment Development," aimed at enhancing the therapeutic development process for mental disorders. This initiative seeks to develop neurophysiological measures as potential assays for treatment research, focusing on pharmacodynamic measures disrupted across mental disorders in both healthy humans and relevant animal species. The program is structured in two phases: the UG3 phase for preliminary studies and assay optimization, followed by the UH3 phase for evaluating assays across species, with the ultimate goal of generating actionable data to bridge the gap between animal models and human studies. Interested applicants can find more information and guidelines at the NIH website, with applications due by June 20, 2025, and a total project period of up to five years based on milestone achievements.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    PAR-23-087-Full-Announcement.html
    PAR-23-087.html
    The Department of Health and Human Services, through the National Institutes of Health (NIH), has issued a Funding Opportunity Announcement (FOA) titled "Novel Assays to Address Translational Gaps in Treatment Development" aimed at improving the therapeutic development process for mental disorders. The initiative seeks to develop neurophysiological measures as potential assays for treatment research, focusing on pharmacodynamic measures disrupted across mental disorders in both healthy humans and relevant animal species. The FOA is structured in two phases: the UG3 phase, which supports preliminary studies and assay optimization, and the UH3 phase, which evaluates assays in parallel across species. This funding opportunity encourages collaborations among neuroscientists to establish reliable in vivo functional brain assays that are applicable in both preclinical and clinical contexts. The goal is to generate actionable data that can bridge the gap between animal models and human studies, ultimately enhancing the efficiency and effectiveness of new therapeutic interventions. The applications must adhere strictly to the provided guidelines, with potential applicants encouraged to read related notices before submission. Multiple awards may be provided based on NIH funding availability, and the total project period could last up to five years, contingent on achieving specific milestones.
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