The National Institutes of Health (NIH) has posted a grant opportunity titled "Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)". This grant aims to support investigators in the discovery of in vivo chemical probes for novel brain targets. The purpose is to stimulate research in the development of small molecules for understanding biological processes relevant to the missions of the National Institute of Mental Health (NIMH), National Institute on Drug Abuse (NIDA), National Eye Institute (NEI), and/or National Institute on Aging (NIA). Additionally, the grant seeks to discover and validate novel biological targets that will inform studies of brain disease mechanisms. Projects that provide new insight into important disease-related biological targets and processes will be given emphasis. The grant does not require cost sharing or matching. The eligible applicants include various institutions and organizations such as Alaska Native and Native Hawaiian Serving Institutions, Faith-based or Community-based Organizations, and U.S. Territories or Possessions. The closing date for this grant opportunity is January 7, 2027. For more information and to apply, visit the following link: Discovery of in vivo Chemical Probes for the Nervous System Grant. For any inquiries, contact NIH Grants Information at grantsinfo@nih.gov.