The Department of Health and Human Services, through the National Institutes of Health (NIH), announces a funding opportunity aimed at supporting research utilizing invasive neural recording methods in humans to advance understanding of mental health disorders. This R21 exploratory/developmental grant encourages innovative, high-risk applications that target gaps in knowledge regarding neural circuitry associated with complex moods and cognitive behaviors. Researchers are encouraged to form diverse teams incorporating various scientific disciplines and address pressing mental health questions, utilizing state-of-the-art tools and methodologies. The estimated budget for this grant is capped at $275,000 for a two-year project period. Applications, which must include a Plan for Enhancing Diverse Perspectives to foster inclusivity, are due beginning January 16, 2025, with a maximum expiration date for proposals set for January 8, 2028. The initiative seeks to bridge the gap between basic neuroscience and applied mental health interventions, paving the way for future therapeutic advancements in brain stimulation technologies and fostering collaborative research environments in mental health studies.