Elucidating Immunometabolic Responses to HIV Infection that Increase TB or HBV Risk (R21 Clinical Trial Not Allowed)
ID: 357822Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/357822

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-25-316.html
Timeline
    Description

    The National Institutes of Health (NIH) has announced a funding opportunity titled "Elucidating Immunometabolic Responses to HIV Infection that Increase TB or HBV Risk," aimed at supporting research into the immunometabolic changes induced by HIV in individuals undergoing combination antiretroviral therapy. This initiative seeks to investigate how these alterations affect immune responses and increase the risk of subsequent infections, specifically tuberculosis (TB) and hepatitis B virus (HBV). The funding opportunity is particularly significant for advancing understanding in the field of HIV-related health risks and aims to foster innovative research approaches, including the use of machine learning and AI to identify biomarkers and therapeutic targets. Eligible applicants can receive up to $275,000 over two years, with applications due by January 7, 2028. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/pa-files/PAR-25-316.html.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    PAR-25-316-Full-Announcement.html
    PAR-25-316.html
    The Department of Health and Human Services, via the National Institutes of Health (NIH), announced a funding opportunity (FON) titled "Elucidating Immunometabolic Responses to HIV Infection that Increase TB or HBV Risk" under the R21 Exploratory/Developmental Research Grant mechanism. This initiative aims to support research investigating how HIV-induced immunometabolic changes in individuals on combination antiretroviral therapy affect immune responses and the risk of subsequent long-term infections, specifically tuberculosis (TB) and hepatitis B virus (HBV). The total funding for projects is capped at $275,000 over two years, and applications are due in 2025 and 2026. Eligible applicants include various educational and nonprofit institutions as well as for-profit organizations, and applicants are encouraged to form interdisciplinary teams for comprehensive research. This funding opportunity particularly seeks innovative research approaches, including the application of machine learning and AI, to define immune cell metabolic alterations during HIV infections. The goal is to identify biomarkers for disease progression and potential therapeutic targets to mitigate TB and HBV risk in people living with HIV. Applications not focusing on this scope, clinical trials, or that do not meet submission requirements will be deemed non-responsive.
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