The Department of Health and Human Services, through the National Institutes of Health (NIH), announces a funding opportunity aimed at exploring HIV cure strategies in relation to the initiation of combination antiretroviral therapy (cART). The primary goal is to identify interventions that can enhance treatment-free remission rates when administered at the onset of cART or after an analytical treatment interruption (ATI). This Notice of Funding Opportunity (NOFO) invites R21 applications, supporting shorter-term exploratory research (up to two years) with a maximum budget of $275,000. The research should focus on novel interventions and basic research into HIV reservoir dynamics and decay, as well as optimizing immune responses against HIV. All applications must comply with instructions from the NIH Grants Policy Statement, and diversity in research teams is encouraged. This initiative highlights the NIH's commitment to addressing HIV through innovative research while fostering scientific diversity and inclusion. The announcements regarding application due dates range from December 7, 2023, with a final expiration set for September 8, 2026, ensuring ample opportunity for submission.