The Department of Health and Human Services, through the National Institutes of Health (NIH), has issued a Notice of Funding Opportunity (NOFO) titled "Opportunities for HIV Cure Strategies at the Time of ART Initiation" (R01). This funding initiative aims to research new cure strategies for HIV that can be applied at the onset of combination antiretroviral therapy (cART) or upon restarting cART after treatment interruptions. The goal is to identify methods that lead to sustained treatment-free remission of HIV. Applications must adhere to strict guidelines and cannot involve clinical trials. Eligible applicants include various institutions such as higher education and nonprofit organizations, and all proposals will be evaluated based on scientific merit, significance, innovation, approach, and investigator qualifications. The review process will focus on the potential impact of the proposed research on the field of HIV treatment. Key dates include application submission deadlines starting December 7, 2023, with funding for meritorious projects contingent on NIH appropriations. This initiative emphasizes interdisciplinary collaboration and encourages participation from underrepresented groups to promote innovation and progress in HIV cure research.