The National Institutes of Health (NIH), through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), is announcing a funding opportunity titled "Priority HIV/AIDS Research" under the R01 grant mechanism. This initiative aims to stimulate research that aligns with NIH’s priorities regarding HIV/AIDS, particularly focusing on systemic complications such as metabolic, gastrointestinal, and kidney issues arising from HIV. The anticipated funding amount is $2 million, with an expectation to support 3 to 5 awards over five years. Applications are due on various specific dates starting from May 7, 2025, with eligibility open to a wide range of organizations, including higher education institutions and nonprofits. Investigators are encouraged to incorporate health-impeding social determinants of health into their research proposals, highlighting their role in HIV-related comorbidities. The streamline submission process includes application preparation through Grants.gov or the NIH ASSIST system, with strict adherence to application guidelines emphasized. Successful proposals will undergo a rigorous peer review, assessing the research significance, innovation, rigor, and potential impact. This funding opportunity highlights NIH’s commitment to advancing understanding of the intersection between HIV and related health conditions, promoting comprehensive research to improve public health outcomes.