Targeting Cell Surface HIV Envelope for Cell Elimination (R01 Clinical Trial Not Allowed)
ID: 357488Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/357488

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-25-300.html
Timeline
    Description

    The National Institutes of Health (NIH) is inviting applications for the grant opportunity titled "Targeting Cell Surface HIV Envelope for Cell Elimination (R01 Clinical Trial Not Allowed)." This funding initiative aims to support research focused on the HIV-1 Envelope (Env), specifically investigating its cell surface expression, the mechanisms of biologic-mediated cell killing, and the development of innovative strategies to enhance the recognition and elimination of HIV-infected cells. The research is critical for advancing immunotherapies and targeted vaccines for HIV-1 prevention and cure. Eligible applicants include a wide range of institutions, particularly those representing underrepresented groups, with applications due by January 7, 2028. For further details, interested parties can contact NIH Grants Information at grantsinfo@nih.gov or visit the official announcement at https://grants.nih.gov/grants/guide/pa-files/PAR-25-300.html.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    PAR-25-300-Full-Announcement.html
    PAR-25-300.html
    The National Institutes of Health (NIH) is soliciting applications for research projects focused on targeting the HIV-1 Envelope (Env) to eliminate HIV-infected cells, as described in their funding opportunity announcement (FON) PAR-25-300. The program aims to delve into the mechanisms of Env's cell surface expression and biologic-mediated killing, ultimately contributing to immunotherapies and vaccines for HIV-1. Eligible applicants include various institutions and organizations, with an emphasis on supporting diverse entities, especially those representing underrepresented groups. The application process begins on April 7, 2025, with key deadlines spanning through to early 2028. Proposals must align with specified research objectives, particularly those exploring Env surface expression dynamics and the development of biologics capable of targeting HIV-infected cells. Applications focused exclusively on transcriptional control, latency reversal agents, or broadly neutralizing antibodies will not be reviewed. The NIH emphasizes compliance with application guidelines and encourages early submission to address potential issues in the application process. This funding opportunity underscores the NIH's commitment to advancing scientific understanding of HIV and enhancing strategies for the treatment and prevention of this infection.
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