The National Institutes of Health (NIH) is offering a funding opportunity titled "Towards a Better Understanding of the Neurological Effects of Infection-Associated Chronic Illnesses" (R21 - Clinical Trial Optional) aimed at supporting research into the neurological and mental health outcomes associated with chronic illnesses linked to infections, including the post-acute sequelae of COVID-19 (Neuro-PASC). The initiative encourages applications that investigate the mechanisms underlying these conditions, with a particular interest in studies that explore common pathophysiologies across various infection-associated chronic illnesses such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and postural orthostatic tachycardia syndrome (POTS). Eligible applicants include a wide range of organizations, including higher education institutions and nonprofits, with a maximum funding amount of $275,000 available for a two-year project period. Applications are due by 5:00 PM local time on November 16, 2025, and interested parties can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries.