The National Institutes of Health (NIH) is forecasting a funding opportunity announcement for research aimed at accelerating the pace of substance use research using existing data, specifically under the R01 grant mechanism. This initiative seeks to promote innovative research projects that leverage existing datasets to enhance understanding and treatment of substance use disorders, with the goal of fostering meaningful collaborations among researchers. The estimated total program funding is $2 million, with approximately three awards expected to be made, and the anticipated application due date is in Spring 2025, following the publication of the Notice of Funding Opportunity in Fall 2024. For further details, potential applicants should prepare to submit their proposals by the estimated close date of June 17, 2025, with awards expected to be announced by April 1, 2026.