Exploratory Clinical Neuroscience Research on Substance Use Disorders (R61/R33 Basic Experimental Studies with Humans (BESH) Required)
Grant Opportunity Analysis
The National Institutes of Health (NIH) has announced a Notice of Funding Opportunity (NOFO) for exploratory clinical neuroscience research on substance use disorders (SUD) through the R61/R33 phased grant mechanism. This initiative aims to enhance understanding of the neurobiological mechanisms underlying SUD, encouraging innovative studies that explore fundamental brain functions and behaviors related to substance use. The program supports clinical research that integrates both basic research and clinical trials, with funding available for up to five years—two years for the R61 phase and three years for the R33 phase, contingent upon achieving defined milestones. Interested applicants from diverse institutions, including higher education and non-profit organizations, are encouraged to submit proposals by May 7, 2026. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/pa-files/PAR-23-158.html.
Eligible Applicants
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.