The National Institutes of Health (NIH) is issuing a funding opportunity titled "Accelerating the Pace of Substance Use Research Using Existing Data" through the National Institute on Drug Abuse (NIDA). The goal is to support innovative analysis of existing datasets related to substance use behaviors—like alcohol, tobacco, and illicit substances—and their links to health outcomes, including HIV. This exploratory research grant (R21) allows applications exclusively focused on analyzing existing data rather than collecting new data. The funding aims to foster research that elucidates risk factors, treatment efficacy, and service delivery improvements for substance use disorders. A total of $2 million will be distributed for projects over two years, with an application budget cap of $275,000. Eligible applicants include universities, nonprofit organizations, and various public institutions. Key dates include an earliest application submission date of June 17, 2025, with a maximum grant period of two years. Applications must be submitted electronically through the Grants.gov system, and compliance with NIH application guidelines is mandatory. The emphasis on utilizing existing data sets is intended to maximize research insights without the costs of new data collection.