The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) for the initiative titled "NIDA REI: Reaching Equity at the Intersection of HIV and Substance Use," aimed at addressing HIV-related health disparities in underserved racial and/or ethnic populations. This funding opportunity will solicit research applications that propose novel approaches to tackle these critical health issues, with a focus on fostering meaningful collaborations among applicants. The estimated total program funding for this initiative is $2,000,000, with the NOFO expected to be published in Summer 2025 and applications due in Winter 2025. Interested researchers should prepare to submit their proposals by the anticipated deadlines, with awards expected to be made by July 1, 2026.