The National Institutes of Health (NIH) is inviting applications for the Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required), aimed at supporting innovative research with the potential to significantly impact biomedical, behavioral, or clinical disciplines. This funding opportunity is specifically designed for studies that prospectively assign human participants to experimental conditions without predefined application aims, thereby exemplifying basic research within the NIH's definition of clinical trials. The program encourages diverse applicants, including small businesses, educational institutions, and non-profits, to explore pioneering ideas and methodologies, with funding available up to $275,000 over two years, capped at $200,000 per year. Interested applicants should ensure compliance with detailed submission processes and review criteria, and may contact the NIH OER Webmaster at FBOWebmaster@OD.NIH.GOV for assistance. The application deadline is January 7, 2025.