The National Institutes of Health (NIH) is offering a funding opportunity for Research Project Grants (Parent R01) aimed at supporting basic experimental studies involving human participants. This initiative is designed for discrete projects that advance knowledge in biomedical or behavioral research without immediate practical applications, aligning with the NIH's definition of clinical trials. Eligible applicants include a diverse range of institutions such as historically black colleges and universities, tribal colleges, and various community-based organizations, with no cost-sharing requirements. Interested parties should note that applications are due by January 7, 2025, and can find further details and submission guidelines at the NIH's official website or by contacting the NIH OER Webmaster at FBOWebmaster@OD.NIH.GOV.