The Department of Health and Human Services, through the National Institutes of Health (NIH) and the National Institute of General Medical Sciences (NIGMS), has issued a Notice of Funding Opportunity (NOFO) for exploratory research grants (R21) aimed at developing new technologies in biomedical research. This funding opportunity invites applications that propose innovative, yet untested technology concepts with no existing proof of concept, focused solely on technology development rather than addressing specific biological questions. Proposals should aim for high-risk, high-reward projects capable of creating significant tools to advance the biomedical field. The funding limits are set at $275,000 in direct costs over two years, with a maximum of $200,000 in any single year. Eligible applicants include higher education institutions, nonprofits, and government entities, but clinical trials are not allowed in the proposed research. Critical evaluation criteria include the innovation potential of the technology, rigorous experimental design, and overall impact on biomedical research. All applications must adhere to submission guidelines, including a signed letter confirming compliance with responsiveness criteria. The NOFO emphasizes advancing the understanding of biological processes, the importance of the state's art in technology, and the significance of diverse applicant backgrounds.