The National Institutes of Health (NIH) is offering the Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required) to support innovative research projects that include at least one clinical trial. This funding opportunity aims to facilitate exploratory and developmental studies that may involve significant risk but have the potential to lead to breakthroughs in biomedical, behavioral, or clinical research. Eligible applicants include a diverse range of organizations, such as higher education institutions, nonprofits, and foreign entities, with a combined budget cap of $275,000 for a maximum two-year project period, and annual requests not exceeding $200,000. Interested parties should submit their applications by January 7, 2025, and can direct inquiries to the NIH OER Webmaster at FBOWebmaster@OD.NIH.GOV for further assistance.