The National Institutes of Health (NIH) is offering the NIH Exploratory/Developmental Research Grant Program (Parent R21), aimed at supporting innovative research projects in their early stages. This grant program encourages the exploration of novel ideas and methodologies that could lead to significant advancements in biomedical, behavioral, and clinical research, specifically targeting projects that may involve considerable risk but have the potential for breakthrough developments. Eligible applicants include a wide range of organizations, such as higher education institutions, nonprofits, for-profits, and foreign entities, with funding of up to $275,000 available over a maximum project period of two years. Interested parties should note that clinical trial proposals are not accepted, and applications must be submitted by January 7, 2025, with further details available at NIH Grants. For any issues related to the funding announcement, applicants can contact the NIH OER Webmaster at FBOWebmaster@OD.NIH.GOV.