The NIH Exploratory/Developmental Research Grant (Parent R21 Clinical Trial Required) aims to support innovative research projects at the early stages that can lead to significant advancements in biomedical, behavioral, and clinical research. Participating NIH institutes include NEI, NIA, NIAID, and others, which encourage applications demonstrating creativity and addressing crucial gaps in knowledge. The funding opportunity allows for new, resubmission, and revision applications; however, all must propose at least one clinical trial. Eligible applicants include a wide range of organizations such as higher education institutions, nonprofits, and foreign entities. The total project period is limited to two years with a budget of up to $275,000. Applications will be thoroughly evaluated by NIH's peer review system, focusing on scientific merit, innovation, and the feasibility of the proposed work. Key dates include an application opening on January 16, 2025, and the expiration of the funding opportunity on January 8, 2028. The overarching goal is to foster discoveries that enhance health and advance the scientific understanding of diseases, ensuring responsible and impactful research practices.