The Department of Health and Human Services is issuing a Funding Opportunity Announcement (FOA) to support innovative research on brain and nervous system disorders relevant to Low and Middle-Income Countries (LMICs). This initiative, through the National Institutes of Health (NIH), aims to foster collaborative projects that enhance neuro-health research capacity and address the burden of neurological disorders across the lifespan. It encourages applications from both U.S. and LMIC institutions, emphasizing the need for studies on neurological, neurodevelopmental, and neuropsychiatric conditions. Eligible entities include higher education institutions, nonprofits, and government agencies from LMICs and the U.S., with a focus on building sustainable research infrastructure. The application process allows various project types, including those involving clinical trials. A significant emphasis is placed on interdisciplinary approaches that incorporate socio-economic factors and local contexts to improve treatment and intervention strategies. Key deadlines for application submission are specified, alongside guidelines for budgeting, eligibility, and required formats. The FOA encourages applicants to engage in preliminary collaborations and consultations to ensure relevance to the research priorities of participating NIH Institutes. This funding opportunity reflects a commitment to global health advancement by establishing necessary research frameworks in resource-constrained environments.