The National Institutes of Health (NIH) has announced a Notice of Funding Opportunity (NOFO) titled "Cellular and Molecular Biology of Complex Brain Disorders (R01 Clinical Trial Not Allowed)," aimed at advancing research on high-confidence risk factors associated with complex brain disorders. This grant encourages studies that focus on the intracellular, transcellular, and circuit substrates of neural function, allowing for both hypothesis-generating and hypothesis-testing research designs, while discouraging attempts to model the disorders themselves. The initiative is crucial for enhancing understanding of the biological processes impacted by these disorders, ultimately facilitating therapeutic target identification and enriching data resources. Applications are due by September 7, 2026, with no budget cap, and interested parties can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries.