The National Institutes of Health (NIH) is offering the Joint NINDS/NIMH Exploratory Neuroscience Research Grant (R21 Clinical Trial Optional) to support innovative and exploratory research projects in neuroscience. This grant aims to finance early-stage studies that assess the feasibility of novel investigations, with a focus on mechanistic clinical trials or basic experimental studies involving human subjects. The program is designed to encourage high-risk research that has the potential to lead to significant breakthroughs in understanding neuroscience and developing new methodologies or tools. Grants will provide a maximum direct cost of $275,000 over a two-year period, with applications due by January 7, 2025. For further information, interested applicants can contact the NIH OER Webmaster at grantsinfo@nih.gov or visit the funding announcement at http://grants.nih.gov/grants/guide/pa-files/PA-21-219.html.