The National Institutes of Health (NIH) has announced a funding opportunity for the "Drug Discovery for Nervous System Disorders" through the R01 Research Project Grant mechanism. This initiative aims to support the discovery of novel compounds for the prevention and treatment of nervous system disorders, emphasizing innovative approaches in the identification, design, synthesis, and preclinical testing of therapeutic candidates. The funding is particularly relevant for advancing therapies related to mental health, substance use, and aging, with a focus on high-impact research; however, clinical trials are not permitted under this announcement. Interested applicants must submit their proposals by January 7, 2025, and can reach out to the NIH OER Webmaster at OERWebmaster03@od.nih.gov for further inquiries. The funding period may extend up to five years, with no specified budget limits.