The National Institutes of Health (NIH) has announced a funding opportunity titled "Cellular and Molecular Biology of Complex Brain Disorders (R01 Clinical Trial Not Allowed)" aimed at advancing research on high-confidence risk factors associated with complex brain disorders such as schizophrenia and depression. This initiative encourages studies that elucidate the intracellular, transcellular, and circuit substrates of neural function, emphasizing hypothesis generation or testing without artificially modeling the disorders. The funding opportunity is significant for fostering innovative research and collaboration within the scientific community, with applications accepted until September 8, 2026, and no budget limits imposed on proposals. Interested applicants can find more information and submit inquiries via the NIH Grants Information at grantsinfo@nih.gov or through the provided link: https://grants.nih.gov/grants/guide/pa-files/PAR-24-024.html.

PAR-24-024.html

The Department of Health and Human Services, through the National Institutes of Health (NIH), has issued a Notice of Funding Opportunity (NOFO) titled "Cellular and Molecular Biology of Complex Brain Disorders" under the R01 activity code. This funding opportunity encourages research focused on the biology of high-confidence risk factors associated with complex brain disorders, such as schizophrenia and depression. The research should aim to elucidate the intracellular, transcellular, and circuit substrates of neural function without attempting to model these disorders artificially.

Applications may employ various experimental paradigms and should emphasize hypothesis generation or testing while contributing to federally shared data resources. Key dates for application submissions range from October 5, 2023, to September 8, 2026, with no limit on application budgets, reflecting the project's needs. Eligible applicants include higher education institutions and for-profit organizations among others. The NIH stresses the importance of adherence to scientific rigor and encourages the use of novel technologies and resources.

Overall, this NOFO represents a significant funding opportunity aiming to deepen the understanding of complex brain disorders through innovative research while fostering collaboration and data-sharing among the scientific community.

https://grants.nih.gov/grants/guide/pa-files/PAR-24-024.html

This Funding Opportunity Announcement (FOA) encourages research on the biology of high confidence risk factors associated with complex brain disorders, with a focus on the intracellular, transcellular and circuit substrates of neural function. For the purposes of this FOA, the term complex can refer to a multifactorial contribution to risk (e.g., polygenic and/or environmental) and/or highly distributed functional features of the brain disorder. Studies may be either hypothesis-generating (unbiased discovery) or hypothesis-testing in design and may utilize in vivo, in situ or in vitro experimental paradigms, e.g., model organisms or human cell-based assays. While behavioral paradigms and outcome measures can be incorporated into the research design to facilitate the characterization of intracellular, transcellular and circuit mechanisms, these are neither required nor expected. Studies should not attempt to model disorders but instead should aim to elucidate the neurobiological impact of individual or combined risk factor(s), such as the affected molecular and cellular components and their relationships within defined biological process(es). This can include the fundamental biology of these factors, components and processes. The resulting paradigms, component pathways and biological processes should be disseminated with sufficient detail to enrich common and/or federated data resources (e.g., those contributing to the Gene Ontology, Synaptic Gene Ontology, FAIR Data Informatics) in order to bridge the gap between disease risk factors, biological mechanism and therapeutic target identification. The present announcement seeks R01 applications.

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

NIH Grants Information&lt;br/&gt;grantsinfo@nih.gov

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