The Tribal Institutional Review Board Establishment and Enhancement (TIRBEE) grant opportunity, managed by the National Institutes of Health (NIH), seeks to support federally recognized American Indian/Alaska Native (AI/AN) Tribes and their associated entities in establishing or enhancing their Institutional Review Boards (IRBs). This initiative aims to address the historical health disparities experienced by AI/AN populations, partly stemming from past unethical research practices. By strengthening IRBs, TIRBEE intends to promote Tribal autonomy and expertise in overseeing research that involves human participants. Eligible applicants can propose various activities related to IRB establishment or enhancement, including staff recruitment, policy development, and training. The awarded budget per project is capped at $350,000 annually for a maximum of five years, contingent upon NIH funding availability. Applications must comply with rigorous submission guidelines, and only one application per institution is permitted. The funding aims to empower Tribal communities, allowing them to better manage and lead health research that serves their own populations while supporting ethical practices and oversight in biomedical research contexts. The TIRBEE program results from a recommendation to prioritize Tribal participation and leadership in research projects driven by and for their communities.