The National Institutes of Health (NIH) is offering the Tribal Institutional Review Board Establishment and Enhancement (TIRBEE) grant to support federally recognized American Indian/Alaska Native (AI/AN) Tribes and their associated entities in establishing or enhancing their Institutional Review Boards (IRBs). The primary objective of this grant is to empower Tribal communities to oversee research involving human participants, thereby addressing historical health disparities and promoting ethical research practices. This initiative is crucial for fostering Tribal autonomy and expertise in health research, allowing communities to manage studies that directly impact their populations. Eligible applicants can receive up to $350,000 annually for a maximum of five years, with applications due by January 27, 2027. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/pa-files/PAR-24-260.html.